bbcsportsWales begin their Six Nations defence in Scotland, having won only once on their last five trips to Murrayfield.
Inside centre Gavin Henson pulled out with a calf injury, so Tom Shanklin starts in midfield with Jamie Roberts. Scrum-half Mike Phillips is recalled.
Scotland are missing influential duo Euan Murray and Nathan Hines.
Chris Paterson, Scotland's all-time record points scorer, is dropped to the bench, while prop Geoff Cross makes his debut in place of Murray.
With Hines absent, flanker Jason White switches to the second row for just the fifth time in 70 international appearances.
And head coach Frank Hadden has opted against including a specialist lock on the bench, with number eight Simon Taylor providing the only cover if White or Jim Hamilton need to be replaced.
Paterson, who kicked all of Scotland's points in the 21-9 win over Wales in 2007 and in last year's 30-15 defeat in Cardiff, has only recently recovered from a rib injury and his place at full-back goes to Hugo Southwell, while fly-half Phil Godman will take over goal-kicking duties.
With Nikki Walker unavailable through injury, Simon Webster has been preferred to in-form Glasgow winger Thom Evans, with the Edinburgh man getting the nod due to his experience.
Ally Hogg and John Barclay team up with Taylor in the back row, while Gloucester flanker Alasdair Strokosch is a surprise omission from the match-day squad.
Henson and Phillips last played for Wales on the day the team completed the 2008 Grand Slam, having missed the tour of South Africa and the November internationals series through injuries.
Now they are part of a talented group of backs with IRB player of the year Shane Williams on one wing and 20-year-old Leigh Halfpenny given his Six Nations debut on the other.
The visiting pack is unchanged from the eight that beat Australia in November, with Matt Rees and Ian Gough keeping their spots, while Ryan Jones continues as captain and blind-side.
Scrum-half Dwayne Peel is on the bench after being left out of coach Warren Gatland's original 28-man squad for the tournament, Gareth Cooper's knee injury handing Peel a return to Test duty.
Gatland has urged his players to embrace the favourites' tag, rather than view it as a suffocating burden.
And Williams knows Wales must handle such expectation in the right fashion.
"A lot of emphasis has been put on us from outside about being favourites and so on," said the star winger.
"We know we have got to approach this tournament the same as we approach every Six Nations, and that's being full of confidence and fully prepared.
"We've trained really well. We are there or thereabouts in terms of our preparation for the first game.
"But Murrayfield is a tough place to play and we know it is a very good Scotland side. We will need to be on top of our game.
"We are a confident side. There is a confidence in our ability as a team and as individuals, but I don't think we've got a label of arrogance in the squad.
"You've got to have confidence. You can't go into these games thinking you want to do well, you've got to go in with a positive mindset, which is a little bit different from being arrogant."
Having won just one match in each of the last two Six Nations, Hadden is under pressure to deliver a good campaign.
"We prepare to win every match and, after each game, you evaluate your position," he said.
"The competition is so tight this year that losing the first game may not be insurmountable. The important thing is to get ourselves in the mix for the last Saturday of the championship."
:bluenwhitescarf: Hugo Southwell (Edinburgh); Simon Webster (Edinburgh), Ben Cairns (Edinburgh), Graeme Morrison (Glasgow), Sean Lamont (Northampton); Phil Godman (Edinburgh), Mike Blair (Edinburgh); Allan Jacobsen (Edinburgh), Ross Ford (Edinburgh), Geoff Cross (Edinburgh), Jason White (Sale), Jim Hamilton (Edinburgh), Ally Hogg (Edinburgh), Simon Taylor (Stade Francais), John Barclay (Glasgow).
Replacements: Dougie Hall (Glasgow Warriors), Alasdair Dickinson (Gloucester), Kelly Brown (Glasgow Warriors), Scott Gray (Northampton Saints), Chris Cusiter (Perpignan), Chris Paterson (Edinburgh), Max Evans (Glasgow Warriors).
:daggers: Lee Byrne (Ospreys); Leigh Halfpenny (Blues), Jamie Roberts (Blues), Gavin Henson (Ospreys), Shane Williams (Ospreys); Stephen Jones (Scarlets), Mike Phillips (Ospreys); Gethin Jenkins (Blues), Matthew Rees (Scarlets), Adam Jones (Ospreys), Ian Gough (Ospreys), Alun Wyn Jones (Ospreys), Ryan Jones (Ospreys, capt), Martyn Williams (Blues), Andy Powell (Blues).
Replacements: Tom Shanklin (Blues), James Hook (Ospreys), Dwayne Peel (Sale), John Yapp (Blues), Huw Bennett (Ospreys), Luke Charteris (Dragons), Dafydd Jones (Scarlets).
Come on the :scotland: